Company: Northwestern University
Job title: Professor
Rick holds a B.S. from the University of Illinois at Chicago, received a Ph.D. in Biology (laboratory of Professor Murray Rabinowitz) from the University of Chicago in 1978, and conducted postdoctoral research (laboratory of Professor Matthew Meselson) and was a Tutor in Biochemical Sciences at Harvard University in Cambridge, MA. In 1982, Morimoto joined the faculty of the Department of Biochemistry, Molecular Biology, and Cell Biology at Northwestern University in Evanston, IL. He served previously as the Chair of Biochemistry, Molecular Biology, and Cell Biology, the Dean of The Graduate School, and the Associate Provost of Graduate Education at Northwestern University.
Rick’s lab is interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins. Using C. elegans and human iPS cells, the lab employs genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.
Regulation of Proteostasis Networks in Aging & Disease 12:00 pm
• Understanding how the proteostasis network is established in development to protect through reproduction and fails in adulthood and ageing • Mapping out the course of events, including chaperone sequestration, that perpetuate protein aggregation and misfolding – what markers might be predictive of age-associated disease? • Investigating the systemic consequence and communication of protein misfolding…Read more
day: Day One